The concomitant utilization of OXYCONTIN and CYP3A4 inducers can minimize the plasma concentration of oxycodone [see CLINICAL PHARMACOLOGY], leading to lowered efficacy or onset of a withdrawal syndrome in patients who have produced Actual physical dependence to oxycodone [see WARNINGS AND PRECAUTIONS].To inform friends and family with regards to t

For the reason that these reactions were being described voluntarily from the inhabitants of uncertain measurement, It's not often attainable to estimate their frequency reliably or to ascertain a causal marriage to drug publicity.There aren't any effectively-controlled medical experiments evaluating the safety and efficacy with dosing additional u